viral polymerase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T74765	Viral polymerase-IN-1 hydrochloride
	Viral polymerase-IN-1 hydrochloride, a derivative of Gemcitabine, effectively inhibits influenza A and B virus infections, demonstrating IC90 values ranging from 11.4 to 15.9 μM, and possesses activity against SARS-CoV-2...
T0220	Foscarnet sodium	Phosphonoformate	Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
	Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.		Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
T27154	Dexelvucitabine	D-D-4FC,DPC-817,RVT,beta-D-D-4FC,DFC	Reverse Transcriptase
	Dexelvucitabine (RVT), a nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.		Reverse Transcriptase
T1643	Penciclovir	BRL 39123,VSA 671	HCV Protease , Antifection , HSV
	Penciclovir (BRL 39123) is a Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the ...		HCV Protease , Antifection , HSV
T1533	Valganciclovir hydrochloride	Valganciclovir HCl,Valcyt,Valcyte	Others , Antiviral
	Valganciclovir hydrochloride (Valganciclovir HCl) is a hydrochloride salt form of valganciclovir, a prodrug form of ganciclovir, a nucleoside analog of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, v...		Others , Antiviral
T10491	Galidesivir	BCX4430,Immucillin-A	Others
	Galidesivir (BCX4430) is a broad-spectrum antiviral compound, an adenosine analog that inhibits viral RNA-dependent RNA polymerase (RdRp) activity.Galidesivir inhibits a wide range of RNA viral pathogens in vitro, and re...		Others
T3489	Dasabuvir	ABT-333	HCV Protease
	Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra...		HCV Protease
T8736	Cidofovir dihydrate	HPMPC,(S)-HPMPC,GS 0504	Others
	Cidofovir dihydrate (HPMPC) is an anti-CMV drug, It can suppress CMV replication by selective inhibition of viral DNA polymerase and therefore prevention of viral replication and transcription. Cidofovir dihydrate is an ...		Others
T8886	NITD-2		DNA/RNA Synthesis
	NITD-2 is a dengue virus (DENV) polymerase inhibitor, inhibits the DENV RdRp-mediated RNA elongation. NITD-2 penetrates cell membrane poorly. Dengue virus (DENV) is the most prevalent mosquito- borne viral pathogen in hu...		DNA/RNA Synthesis
T67801	GS-6620 PM
	GS-6620 PM is a derivative of GS-6620, an orally administered anti-hepatitis C virus polymerase inhibitor and a novel potent C-nucleoside adenine analogue monophosphate prodrug.GS-6620 has limited activity against other ...
T6446	Clevudine	L-FMAU,Levovir	HBV , DNA/RNA Synthesis
	Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The ...		HBV , DNA/RNA Synthesis
T12526	PP7		Influenza Virus
	PP7 is a potent inhibitor of PB1-PB2 interaction(IC50 of 8.6 μM).		Influenza Virus
T19476	NHC-triphosphate		Others
	NHC-triphosphate is a weak alternative substrate for the viral polymerase and changes the mobility of the product in polyacrylamide electrophoresis gels.		Others
T41002	HCVP-IN-1
	HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.
T11352	Galidesivir triphosphate	BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870	Others
	Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA pol...		Others
T19632	Lobucavir	BMS180194,BMS 180194,SQ 34,514,SQ-34514,SQ 34514,SQ34514
	Lobucavir inhibits the replication of the HIV virus in T cells, monocytes & macrophages in vitro by inhibiting DNA polymerase and viral DNA synthesis.
T10491L	Galidesivir hydrochloride	BCX 4430 hydrochloride,Immucillin-A hydrochloride	Others
	Galidesivir hydrochloride is an inhibitor of viral RNA-dependent RNA polymerase (RdRp). It inhibits SARS-CoV-2 by tightly binding to its RdRp.		Others
T69345	Fosfonet sodium
	Fosfonet sodium is a sodium salt formulation of phosphonoacetic acid with activity against herpes simplex viruses and other members of the herpes virus family. Fosfonet inhibits viral DNA polymerase and inhibits the synt...
T32050	HCV-371	HCV 371
	HCV-371 is a potent selective HCV NS5B polymerase inhibitor that shows broad inhibitory activity against NS5B RDRP and no inhibitory activity against a set of human polymerases (including mitochondrial DNA polymerase γ a...
T73983	Cidofovir diphosphate tri(triethylamine)
	Cidofovir diphosphate triethylamine, an active intracellular metabolite of Cidofovir, acts as a selective inhibitor of viral DNA polymerases. It exhibits inhibitory constants (K_i) of 6.6 μM for human cytomegalovirus (HC...